Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats
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چکیده
منابع مشابه
Interaction of alkylmercuric compounds with sodium selenite. II. Metabolism of methylmercuric chloride administered alone and in combination with sodium selenite in rats.
Repeated doses of sodium selenite (Se) were administered to rats receiving repeated (IV or PO) doses of 0.25 or 2.5 mg Hg/kg methylmercuric chloride (Me2(203)Hg). Se (0.5 mg/kg) was observed to alter the distribution of Me203Hg among tissues as well as among subcellular fractions of kidneys and liver. An excess of selenium resulted in a twofold decrease in the mercury content of kidneys and a s...
متن کاملInteraction of alkylmercuric compounds with sodium selenite. I. Metabolism of ethylmercuric chloride administered alone and in combination with sodium selenite in rats.
The effect of sodium selenite administered intragastrically in repeated doses to rats receiving ethylmercuric chloride po in various repeated doses (0.25 or 2.5 mg Hg/kg) on the excretion, whole-body retention, and organ distribution of mercury was studied. Selenium was found to affect the distribution of ethylmercury among tissues and subcellular fractions of the kidneys and liver as well as i...
متن کاملInteraction of alkylmercuric compounds with sodium selenite. III. Biotransformation, levels of metallothioneinlike proteins and endogenous copper in some tissues of rats exposed to methyl or ethylmercuric chloride with and without sodium selenite.
The biotransformation efficiency of alkylmercurial compounds was studied in rat liver, kidneys, blood, and brain after 2-week administration of methylmercuric chloride (MeHg) and ethylmercuric chloride (EtHg) at doses of 0.25 or 2.5 mg Hg/kg, alone or in combination with sodium selenite (Se) at a level of 0.5 mg Se/kg. Simultaneously, the level of metallothioneinlike proteins (MTP) and endogeno...
متن کاملEffects of Sodium Selenite in Cadmium Chloride Induced Hepatoxicity in Male Sprague-Dawley Rats
The present study aimed to assess the protective role of selenium against cadmium induced hepatotoxicity. The rats were given subcutaneous doses of 1mg/Kg body weight of either normal saline or cadmium chloride or sodium selenite or cadmium chloride plus sodium selenite on alternate days for four weeks. The results showed that cadmium treatment increased hepatic levels of lipid peroxidation, DN...
متن کاملSodium selenite pentahydrate, Na2SeO3·5H2O
In the crystal structure of Na2SeO3·5H2O [disodium selen-ate(IV) penta-hydrate], two Se, two selenite O atoms and one water O atom are located on a mirror plane, and one water O atom is located on a twofold rotation axis. The coordination of one Na(+) cation is distorted trigonal bipyramidal, formed by three equatorial H2O ligands and two axial selenite O atoms. The other Na(+) cation has an oc...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1985
ISSN: 0091-6765
DOI: 10.2307/3429989